Parajely Total Jelly

Analgesic Mechanism: It produces analgesic action by inhibiting the COX pathway in the central nervous system but not in peripheral tissues. It acts within the CNS to increase the pain threshold by inhibiting central cyclo-oxygenase (Both COX-1 & COX-2). 

Anti-Pyretic Mechanism: It also produces antipyretic effect by inhibiting PG synthesis in the central nervous system & blocking the actions of endogenous pyrogens at the hypothalamic thermo-regulatory centres.

Phenylephrine: It possesses both direct and indirect sympathomimetic effects, primarily as a post-synaptic alpha-adrenergic agonist, producing potent vasoconstriction. This constriction of blood vessels leads to reduced blood flow to the nose, decreased amount of blood in the sinusoid vessels, and decreased mucosal edema, which relieves nasal congestion.

Chlorpheniramine: It is a H1-antagonists which compete with free histamine for binding at H1-receptor sites. Blockade of H1-receptors suppresses the formation of edema, flare, and pruritus that result from histaminic activity.