Anapolis Syrup

Camylofin: It is a spasmolytic agent with a potent dualmode of action, i.e., it possesses both Musculotropic&Neurotropic Effect.

Musculotropicaction has a direct papaverine like spasmolytic actionon smooth muscles, where it inhibits the enzymephosphodiesterase IV, which in turn causes an increase inintracellular concentration of cyclic AMP and smoothmuscle relaxation by depletion of intracellular calciumlevels. This is the more predominant action ofCamylofin.

Neurotropic Effect: It has mildatropine like anti-cholinergic effect, whereby it causessmooth muscle relaxation, by inhibiting the binding ofacetylcholine with the muscarinic receptors. Unlike themusculotropicaction, which is comparable to papaverine,the neurotropic action is only 1/7th that of the potency ofatropine.

Paracetamol:

Analgesic Mechanism: It produces analgesic action by inhibiting theCOXpathwayinthecentralnervoussystembutnot in peripheraltissues.ItactswithintheCNStoincreasethepainthresholdbyinhibitingcentralcyclo-oxygenase (Both COX-1 & COX-2).

Anti-Pyretic Mechanism: ItalsoproducesantipyreticeffectbyinhibitingPGsynthesisinthecentralnervoussystem&blockingtheactionsofendogenouspyrogensatthehypothalamicthermo-regulatorycentres.