Anapolis Syrup

Composition: Each 5ml syrup contain Camylofin 12.5mg + Paracetamol 125mg in 60ml Pack.

Formulation: SYRUP

Flavour: Raspberry Flavour

Category:

Therapy:

Camylofin: Antispasmodic (Smooth Muscle Relaxant) /

Paracetamol: Analgesic & Antipyretic

Class:

Camylofin: Anticholinergics Drug

Paracetamol: Para Aminophenol Derivatives

Mechanism of Action:

Camylofin: It is a spasmolytic agent with a potent dual mode of action, i.e., it possesses both Musculotropic & Neurotropic Effect.

Musculo tropic action has a direct papaverine like spasmolytic action on smooth muscles, where it inhibits the enzyme phosphodiesterase IV, which in turn causes an increase in intracellular concentration of cyclic AMP and smooth muscle relaxation by depletion of intracellular calcium levels. This is the more predominant action of Camylofin.

Neurotropic Effect: It has mild atropine like anti-cholinergic effect, whereby it causes smooth muscle relaxation, by inhibiting the binding of acetylcholine with the muscarinic receptors. Unlike the musculotropic action, which is comparable to papaverine, the neurotropic action is only 1/7th that of the potency of atropine.

Paracetamol:

Analgesic Mechanism: It produces analgesic action by inhibiting the COX pathway in the central nervous system but not in peripheral tissues. It acts within the CNS to increase the pain threshold by inhibiting central cyclo-oxygenase (Both COX-1 & COX-2).

Anti-Pyretic Mechanism: It also produces antipyretic effect by inhibiting PG synthesis in the central nervous system & blocking the actions of endogenous pyrogens at the hypothalamic thermo-regulatory centres.

Indications: For Symptomatic Relief in The Treatment of Abdominal Colic or Abdominal Spasmodic Pain Originating from Various Abdominal Viscera like

  • Acute Colicky Abdominal Pain
  • Gastro-Intestinal Colic
  • Renal Colic
  • Biliary Colic
  • Menstrual Colic
  • Pain Associated with Primary Dysmenorrhea.

Dosage & Administration: 5-10ml two to three times in a Day for 5 Days depending on severity of condition

HOW SUPPLIED: ANAPOLIS is available as syrup in 60ml Pack.

References:

  • Mayadeo N. Int J Reprod Contracept Obstet Gynecol. 2019 Jan;8(1):359-367
  • International Journal of Contemporary Pediatrics | August2022| Vol 9| Issue 8Page 706