Therapy/Class:
Therapy: Antibiotics
Class:
Cefpodoxime: Third Generation Cephalosporin
Clavulanic acid: Beta lactamase inhibitor
Mechanism of Action:
Cefpodoxime: It is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has activity in the presence of some beta-lactamases, both cephalosporinases, of Gram-negative and Gram-positive bacteria.
Clavulanic acid: It contains a beta-lactam ring in its structure that binds in an irreversible fashion to beta-lactamases, preventing them from inactivating certain beta-lactam antibiotics, with efficacy in treating susceptible gram-positive and gram-negative infections.
Indications:
In…
- Pharyngitis and/or tonsillitis
- Community-acquired pneumonia
- Acute bacterial exacerbation of chronic bronchitis
- Uncomplicated skin and skin structure infections
- Acute maxillary sinusitis
- Uncomplicated urinary tract infections
Dosage & Administration:
| Infants and Paediatric patients (age 2 months through 12 years) | |||
|---|---|---|---|
| Type of Infection | Total Daily Dose | Dose Frequency | Duration |
| Acute otitis media | 10 mg/kg/day (Max 400 mg/day) | 5 mg/kg Q12 hours (Max 200 mg/dose) | 5 days |
| Pharyngitis and/or tonsillitis | 10 mg/kg/day (Max 200 mg/day) | 5 mg/kg Q 12 hours (Max 100 mg/dose) | 5–10 days |
| Acute maxillary sinusitis | 10 mg/kg/day (Max 400 mg/day) | 5 mg/kg Q 12 hours (Max 200 mg/dose) | 10 days |
HOW SUPPLIED:
Disopod 50CV is available as dry syrup in 30ml pack
Disopod 100CV is available as dry syrup in 30ml pack
References:
- Yatendra Kumar, Neera Tewari, Ram Aryan, Bishwa Rai, Hashim Nizar, “Process for the preparation of cefpodoxime acid.” U.S. Patent US20050020561, issued January 27, 2005.
- Dennis Edward Clark, Shaukat Hussain Malik, Paul Gerard Butterly, Clive Elton Badman, Jeffrey David Haseler, “Process for preparing potassium clavulanate in rossette form.” U.S. Patent US5750685, issued April, 1978.
- Brogden RN, Carmine A, Heel RC, Morley PA, Speight TM, Avery GS. Amoxycillin/clavulanic acid: a review of its antibacterial activity, pharmacokinetics and therapeutic use. Drugs. 1981 Nov;22(5):337-62.
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