Therapy / Class: Antibacterial/Third-Generation Cephalosporin Antibiotic
Spectrum of Coverage
Gram-positive bacteria:
- Staphylococcus aureus (methicillin-susceptible strains, including those producing penicillinases)
- Staphylococcus saprophyticus
- Streptococcus pneumoniae (excluding penicillin-resistant isolates)
- Streptococcus pyogenes
Gram-negative bacteria:
- Escherichia coli
- Klebsiella pneumoniae
- Proteus mirabilis
- Haemophilus influenzae (including beta-lactamase producing isolates)
- Moraxella catarrhalis
- Neisseria gonorrhoeae (including penicillinase-producing isolates)
Mechanism of Action:
Shows bactericidal action by inhibition of bacterial cell wall synthesis. Active against some beta-lactamases, both penicillinasesand cephalosporinases, of Gram-negative and Gram-positive bacteria
Indications:
- Acute otitis media
- Pharyngitis and/or tonsillitis
- Community-acquired pneumonia
- Acute bacterial exacerbation of chronic bronchitis
- Uncomplicated skin and skin structure infections
- Acute maxillary sinusitis
- Uncomplicated urinary tract infections
Dosage & Administration:
| Infants and Pediatric Patients (age 2 months through 12 years) | |||
|---|---|---|---|
| Type of Infection | Total Daily Dose | Dose Frequency | Duration |
| Acute otitis media | 10 mg/kg/day (Max 400 mg/day) | 5 mg/kg Q 12 h (Max 200 mg/dose) | 5 days |
| Pharyngitis and/or tonsillitis | 10 mg/kg/day (Max 200 mg/day) | 5 mg/kg/dose Q 12 h (Max 100 mg/dose) | 5 to 10 days |
| Acute maxillary sinusitis | 10 mg/kg/day (Max 400 mg/day) | 5 mg/kg Q 12 hours (Max 200 mg/dose) | 10 days |
HOW SUPPLIED:
DISOPOD 50 DRY SYRUP is Dry Syrup available as 30ml packs with Sterile Water
DISOPOD 100 DRY SYRUP is Dry Syrup available as 30ml packs with Sterile Water
References:
- J Clin DiagnRes . 2017 Jun;11(6):FC01-FC04.
- Journal of Antimicrobial Chemotherapy (2002) 50, Topic T1, 23–27
- Drugs Context. 2020; 9: 2020-9-3.
