THERAPY/CLASS: Anti-Emetic/ Prokinetic
Mechanism of Action:
It is a peripheral dopamine antagonist structurally related to the butyrophenones with antiemetic and gastroprokinetic properties. Its action is related to its peripheral dopamine receptor blocking properties. Emesis induced by apomorphine, hydergine, morphine or levodopa through stimulation of the chemoreceptor trigger zone (situated outside the blood-brain barrier) can be blocked by domperidone. There is indirect evidence that emesis is also inhibited at the gastric level, since domperidone also inhibits emesis induced by oral levodopa, and local gastric wall concentrations.
Indications:
- Gastroesophageal reflux disease (GERD)
- Nausea
- Vomiting
- Indigestion
- Gastroparesis
DOSAGE AND ADMINISTRATION:
1 Month-12 Yrs.: 200-400mcg/kg/dose 3-4 times a day before food
12-18 Yrs.: 10-20mg 3-4 times a day
HOW SUPPLIED:
- DOMDROPS is available as Drops in 10 ml pack.
References:
- De Loore I, Van Ravensteyn H, Ameryckx L. Domperidone drops in the symptomatic treatment of chronic paediatric vomiting and regurgitation. A comparison with metoclopramide. Postgraduate medical journal. 1979 Jan 1; 55:40-2.
- Sanklecha M. Domperidone overdose. Reactions. 2014 Jan 16; 1484:16-8.
- Patil HG, Tiwari RV, Repka MA, Singh KK. Formulation and development of orodispersible sustained release tablet of domperidone. Drug development and industrial pharmacy. 2016 Jun 2;42(6):906-15.
