Therapy/Class:
Therapy
Phenylephrine: Decongestant
Chlorpheniramine: Antiallergic
Class
Phenylephrine: Selective Alpha-1 Adrenergic Agonist
Chlorpheniramine: Antihistamine H1 Receptor Antagonist
Mechanism of Action:
Chlorpheniramine: It has H1-antagonist activity belonging to the alkylamine class of antihistamines and it appear to compete with histamine for receptor sites on effector cells. It antagonizes the allergic response vasodilatation, increased vascular permeability, increased mucus secretion of nasal tissue.
Phenylephrine: It stimulates alpha-adrenergic receptors on the nasal mucosa (direct effect) causing vasoconstriction of local vessels. The vasoconstrictive action decreases mucosal edema, leading to a decongestant effect.
Indications:
- For relief of coughs and upper respiratory symptoms, including nasal congestion, associated with Allergy & Common Cold
Dosage & Administration:
For Children Aged 6 to 11 years of age:
KID-ZUKAM JR SYRUP: 2.5ml to 5ml every 4 to 6 hours.
HOW SUPPLIED:
References:
- International Journal of Contemporary Medical Research ISSN (Online): 2393-915X; (Print): 2454-7379 | ICV: 98.46, Volume 6 | Issue 3 |March 2019
- de Oliveira GG, Feitosa A, Loureiro K, Fernandes AR, Souto EB, Severino P. Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures. Saudi Pharm J. 2017 Jan;25(1):99-103. doi: 10.1016/j.jsps.2016.05.001. Epub 2016 May 7. PMID: 28223869; PMCID: PMC5310159
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