Therapy/Class:
Therapy
Phenylephrine: Decongestant
Chlorpheniramine: Antiallergic
Paracetamol: Analgesics with Antipyretic
Class
Phenylephrine: Selective Alpha-1 Adrenergic Agonist
Chlorpheniramine: Antihistamine H1 Receptor Antagonist
Paracetamol: Para Aminophenol Derivatives
Mechanism of Action:
Phenylephrine: It stimulates alpha-adrenergic receptors on the nasal mucosa (direct effect) causing vasoconstriction of local vessels. The vasoconstrictive action decreases mucosal edema, leading to a decongestant effect.
Chlorpheniramine: It has H1-antagonist activity belonging to the alkylamine class of antihistamines and it appear to compete with histamine for receptor sites on effector cells. It antagonizes the allergic response vasodilatation, increased vascular permeability, increased mucus secretion of nasal tissue.
Paracetamol: Paracetamol primarily raises the pain threshold in the central nervous system (CNS) by inhibiting COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis. Its antipyretic properties result from direct effects on the hypothalamus, promoting peripheral vasodilation, sweating, and heat dissipation.
Indications:
- For relief of coughs and upper respiratory symptoms, including nasal congestion, associated with Fever, Allergy & Common Cold
Dosage & Administration:
For Children Aged 2 to Under 6 years of age:
KID-ZUKAM SUSPENSION: 1.25ml to 2.5ml every 4 to 6 hours.
HOW SUPPLIED:
- KID-ZUKAM SUSPENSION is available as Suspension in 60ml Pack.
References:
- Picon PD, Costa MB, da Veiga Picon R, Fendt LC, Suksteris ML, Saccilotto IC, Dornelles AD, Schmidt LF. Symptomatic treatment of the common cold with a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine: a randomized, placebo-controlled trial. BMC Infect Dis. 2013 Nov 22;13:556. doi: 10.1186/1471-2334-13-556. PMID: 24261438; PMCID: PMC4222817.
- Zhang Y, Mallefet P. Time-to-onset of cold and flu symptom relief: A randomized, double-blind, placebo-controlled pilot study for a multi-symptom combination product. Int J Clin Pharmacol Ther. 2018 Dec;56(12):604-611. doi: 10.5414/CP203259. PMID: 30220290.
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