Lefclin-O Suspension

Levofloxacin: It is a L-isomer of the racemate, ofloxacin, a quinolone antimicrobial agent. The antibacterial activity of ofloxacin resides primarily in the L-isomer. The mechanism of action of levofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Ornidazole: It is a newer 5-nitroimidazole class of antibiotic with superior efficacy and longer duration of action. It has an antibacterial effect like that of metronidazole and other 5-nitroimidazoles. It kills susceptible microorganisms by interfering with DNA functioning. It acts selectively against microorganisms with enzyme systems capable of reducing the nitro group and catalyzing the interaction between ferredoxin proteins and nitro compounds. After the drug penetrates the microbial cell, the mechanism of its action is based on reducing the nitro group under the influence of the microorganism’s nitroreductases and the activity of the reduced nitroimidazole. The reduction products create compounds with DNA causing it to degrade and disrupt the DNA replication and transcription processes. Furthermore, the drug’s metabolism products have cytotoxic properties and disrupt cellular respiration processes.