Oflopedia-MS & Oflopedia-MS Forte

Ofloxacin: Bactericidal at concentrations equal to orslightly greater than inhibitory concentrations. It inhibits bacterialtopoisomerase IV & DNA gyrase (both of which are type II topoisomerases),enzymes required for DNA replication, transcription, repair, and recombination.

Metronidazole: It occurs through a four-step process. Step one is the entry into the organism by diffusion across the cell membranes of anaerobic and aerobic pathogens. However, antimicrobial effects are limited to anaerobes. Step two involves reductive activation by intracellular transport proteins by altering the chemical structure of pyruvate-ferredoxinoxido-reductase. The reduction of metronidazole creates a concentration gradient in the cell that drives uptake of more drugs and promotes free radical formation that is cytotoxic. Step three, interactions with intracellular targets, is achieved by cytotoxic particles interacting with host cell DNA resulting in DNA strand breakage and fatal destabilization of the DNA helix. Step four is the breakdown of cytotoxic products

Simethicone: It acts by decreasing the surface tension of gas bubbles in the GI tract. This action results in coalescence and dispersion of the gas bubbles allowing their removal from the GI tract as flatulence or belching. Simethicone causes the gas bubbles to accumulate and therefore pass more easily either through the upper GI or lower GI opening.