Therapy/Class:
Therapy
Piracetam: Neuroprotective & Anticonvulsant
Methylcobalamin: Neuro-Regenerative Agent
Class
Piracetam: Nootropic Cyclic GABA Derivative
Methylcobalamin: Activated Form of Vitamin B12
Mechanism of Action:
Piracetam: It interacts with the polar heads in the phospholipid’s membrane and the resulting mobile drug-lipid complexes are thought to reorganize the lipids and influence membrane function and fluidity. Such interaction has been reported in a study that investigated the effects of neuronal outgrowth induced by beta amyloid peptides; while amyloid peptides cause lipid disorganization within the cell membranes leading to neuronal death, so piracetam demonstrated to decrease the destabilizing effects of amyloid peptide.
Methylcobalamin: It exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity.
Indications:
- Symptomatic Improvement of Memory and Intellectual Impairment
- Treatment of Cognitive deficits caused by injuries, craniocerebral
- Treatment of Learning disorders
- Treatment of Cognitive dysfunctions & Impairment
- Treatment of Giddiness caused by injuries, craniocerebral
- Also Helps improvement in children with learning difficulties associated with the written word, particularly with textual understanding
Dosage & Administration:
40-50mg/kg/Day in 3 Divided Doses orally
Decrease the dose by half once the desired effect is achieved
HOW SUPPLIED:
PIRALEXIA SYRUP is available as Syrup in 100ml Pack
References:
- Abbaskhanian A, Ehteshami S, Sajjadi S, Rezai MS. Effects of piracetam on pediatric breath holding spells: a randomized double blind controlled trial. Iran J Child Neurol. 2012 Fall;6(4):9-15. PMID: 24665274; PMCID: PMC3943019.
- Di Ianni M, Wilsher CR, Blank MS, Conners CK, Chase CH, Funkenstein HH, Helfgott E, Holmes JM, Lougee L, Maletta GJ, et al. The effects of piracetam in children with dyslexia. J Clin Psychopharmacol. 1985 Oct;5(5):272-8. doi: 10.1097/00004714-198510000-00004. PMID: 3900148
- Chiarenza GA, Ragaini C, Guareschi Cazzullo A. The acute and chronic administrations of piracetam affect the movement-related brain macropotentials. Int J Psychophysiol. 1990 Apr;8(3):223-34. doi: 10.1016/0167-8760(90)90014-5. PMID: 2338403.