Prolintus LS Syrup

Composition: Each 5ml contains Levosalbutamol 1mg as Syrup in 100ml pack.

Formulation: Syrup

Flavour: Cherry Flavour

Category:

Therapy/Class:

Therapy:
Bronchodilators
Class:
Beta2-Adrenergic Receptors agonist

Mechanism of Action:

Levosalbutamol:
It activates beta2-adrenergic receptors on airway smooth muscle leads to the activation of adenyl cyclase and to an increase in the intracellular concentration of cyclic-3′, 5′-adenosine monophosphate (cyclic AMP). The increase in cyclic AMP is associated with the activation of protein kinase A, which, in turn, inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in muscle relaxation. It relaxes the smooth muscles of all airways, from the trachea to the terminal bronchioles. Increased cyclic AMP concentrations are also associated with the inhibition of the release of mediators from mast cells in the airways.

Indications:

  • For The Treatment or Prevention of Bronchospasm in Adults, Adolescents, And Children (6–11 Years Old) With Reversible Obstructive Airway Disease.

Dosage & Administration:

Adolescents (Above 12 Years of Age)

  • 5–10 ml three times daily.

Children (Aged 6–11 Years)

  • 5 ml three times daily.

Indications:

  • Preventing or alleviating bronchospasm associated with bronchial asthma, chronic bronchitis and managing bronchospasm in other chronic bronchopulmonary disorders.

HOW SUPPLIED: PROLINTUS LS Syrup is available as Syrup in 100ml pack.

References:

  1. Gupta MK, Singh M. Evidence based review on levosalbutamol. Indian J Pediatr. 2007 Feb;74(2):161-7.
  2. Patel, N. C., Patel, D. B., & Chaudhari, P. K. (2013).
  3. Gawchik SM, Saccar CL, Noonan M, Reasner DS, DeGraw SS. The safety and efficacy of nebulized levalbuterol compared with racemic albuterol and placebo in the treatment of asthma in pediatric patients. J Allergy Clin Immunol. 1999 Apr;103(4):615-21.