Spectrum of Coverage:
- Aerobic & facultative Gram-positive microorganisms
> Enterococcus faecium (vancomycin-resistant strains only)
> Staphylococcus aureus (including methicillin-resistant strains)
> Streptococcus agalactiae
> Streptococcus pneumoniae (including multi-drug resistant isolates [MDRSP]
> Streptococcus pyogen
- Aerobic & facultative Gram-negative microorganisms
> Pasteurella multocida
Spectrum of Coverage:
> Inhibits bacterial protein synthesis
> Bacteriostatic against Enterococci & Staphylococci Strains whereas, bactericidal against Streptococci & majority of bacterial strain
> Binds to 23S ribosomal RNA of the 50S subunit & prevents the formation of a functional 70S initiation complex which is an essential component of the bacterial translation process.
Indications:
> Vancomycin-Resistant Enterococcus faecium infections
> Nosocomial pneumonia
> Complicated skin & skin structure infections, including diabetic foot infections, without concomitant osteomyelitis
> Uncomplicated skin & skin structure infections
> Community-acquired pneumonia
Dosage & Administration:
| Infection* | Pediatric Patients (Birth through 11 Years of Age) | Adolescents & Adults (12 Years & Older) | Recommended Duration of Treatment (Consecutive Days) |
| Nosocomial pneumonia | 10 mg/kg every 8 hours | 600 mg 12 hours | 10 to 14 |
| Community-acquired pneumonia, including concurrent bacteremia | |||
| Complicated skin and skin structure infections | |||
| Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia | 10 mg/kg every 8 hours | 600 mg every 12 hours | 14 to 28 |
| Uncomplicated skin and skin structure infections | <5 yrs: 10 mg/kg every 8 hours 5-11 yrs: 10 mg/kg every 12 hours | Adolescents: 600 mg every 12 hours Adults: 400 mg every 12 hours | 10 to 14 |
HOW SUPPLIED:
> 30 ml Oral Dry Syrup is available in Dry Powdered form with Sterile Water.
References:
> Fine MJ, Auble TE, Yealy DM, et al. A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia. The New England Journal of Medicine. 1997;336 (4):243-250.
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