Bendigo Plus Suspension

Composition: 

Each 5ml contains Ivermectin 3mg + Albendazole 200mg in suspension in 10ml Pack.

Formulation: Suspension

Flavour: Orange Flavour

Category:

Therapy / Class:

Therapy: Anti-Helmintic Anti-Parasitic Agent

Class: Benzimidazole (Albendazole) &Avermectins (Ivermectin)

Spectrum of Coverage:

Active against the larval forms ofthe following organism

  • Echinococcusgranulosus
  • Taeniasolium
  • Strongyloidesstercoralis
  • Onchocerca volvulus

Mechanism of Action:

Albendazole: It works by inhibiting protein synthesis by binding to the 50S ribosomal subunit & directly preventing the formation of bacterial protein. On a molecular level, chloramphenicol inhibits the attachment of transfer RNA to the A site on the 50S ribosome.

Ivermectin: It selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyper-polarization of the nerve or muscle cell, resulting in paralysis and

Indications:

Treatment of Parasitic worm infections like

  • Hydatid Cyst Disease
  • Neurocysticercosis
  • Cysticercosis
  • Ascariasis (Roundworm Infection)
  • Capillariasis
  • Secondary Treatment of Cutaneous Larva Migrans
  • Microsporidiosis& Secondary Microsporidiosis Prophylaxis
  • Strongyloidiasis of the Intestinal Tract
  • Trichinosis
  • Enterobiasis (Pinworm Infection)
  • Hookworm Infection
  • Trichuriasis (Whipworm Infection)
  • Giardiasis
  • Onchocerciasis

Dosage & Administration:

Onchocerciasis: Albendazole 400mgplus Ivermectin0.15 mg/kg as Single Dose to be repeated as per condition of patients.

Strongyloidiasis: Albendazole 400mg plus Ivermectin 0.20 mg/kg as Single Dose to be repeated as per condition of patients.

Cutaneous larva migrans: Albendazole: 5 mg/kg/day plus Ivermectin 0.2 mg/kg/dose to be repeated as per conditionof patients.

HOW SUPPLIED:  

BENDIGO PLUS SUSPENSION is available as oral suspension in10ml Pack.

References:

  1. Indian Pediatr. 2022 Dec 15;59(12):916-919. Epub 2022 Oct 29.
  2. Perth Children’s Hospital Children’s Antimicrobial Management Program (ChAMP)
  3. Am J Trop Med Hyg . 1999 Mar;60(3):479-86.
  4. Lancet Infect Dis 2022;22: 123–35

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