Therapy / Class:
Therapy
Aceclofenac: Analgesics & Anti-inflammatory
Paracetamol: Analgesics & Antipyretic
Class
Aceclofenac: Non-Steroidal Anti-Inflammatory Drug (NSAIDs)
Paracetamol: Para Aminophenol Derivatives
Mechanism of Action:
Aceclofenac: Its Anti-Inflammatory action is based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.
Paracetamol: It inhibits the COX pathway in the central nervous system but not the peripheral tissues. It acts within the CNS to increase the pain threshold by inhibiting central cyclooxygenase, an enzyme involved in prostaglandin (PG) synthesis. Paracetamol inhibits both isoforms of central cyclooxygenase, COX-1 and COX-2, but seems to reduce COX activity by a different mechanism than the nonsteroidal anti-inflammatory drugs.
Indications:
In Management of Pain & Inflammation associated with….
- Trauma & Injury
- Dental pain
- Post Vaccination
- Otitis Media
- Joints & Muscular Pain
Dosage & Administration:
- 5ml BID for 3 to 5 Days
HOW SUPPLIED: ACEPEDIA is available as suspension in 60ml pack.
References:
- Iolascon G, Giménez S, Mogyorósi D. A Review of Aceclofenac: Analgesic and Anti-Inflammatory Effects on Musculoskeletal Disorders. J Pain Res. 2021 Nov 30;14:3651-3663. doi: 10.2147/JPR.S326101. PMID: 34876850; PMCID: PMC8643213.
- Legrand E. Aceclofenac in the management of inflammatory pain. Expert Opin Pharmacother. 2004 Jun;5(6):1347-57. doi: 10.1517/14656566.5.6.1347. PMID: 15163279.
- CADTH Rapid Response Report: Summary with Critical Appraisal Srabani Banerjee and Robyn Butcher. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 May 5.