Therapy / Class:
Therapy: Anti-Helmintic Anti-Parasitic Agent
Class: Benzimidazole (Albendazole) &Avermectins (Ivermectin)
Spectrum of Coverage:
Active against the larval forms ofthe following organism
- Echinococcusgranulosus
- Taeniasolium
- Strongyloidesstercoralis
- Onchocerca volvulus
Mechanism of Action:
Albendazole: It works by inhibiting protein synthesis by binding to the 50S ribosomal subunit & directly preventing the formation of bacterial protein. On a molecular level, chloramphenicol inhibits the attachment of transfer RNA to the A site on the 50S ribosome.
Ivermectin: It selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyper-polarization of the nerve or muscle cell, resulting in paralysis and
Indications:
Treatment of Parasitic worm infections like
- Hydatid Cyst Disease
- Neurocysticercosis
- Cysticercosis
- Ascariasis (Roundworm Infection)
- Capillariasis
- Secondary Treatment of Cutaneous Larva Migrans
- Microsporidiosis& Secondary Microsporidiosis Prophylaxis
- Strongyloidiasis of the Intestinal Tract
- Trichinosis
- Enterobiasis (Pinworm Infection)
- Hookworm Infection
- Trichuriasis (Whipworm Infection)
- Giardiasis
- Onchocerciasis
Dosage & Administration:
Onchocerciasis: Albendazole 400mgplus Ivermectin0.15 mg/kg as Single Dose to be repeated as per condition of patients.
Strongyloidiasis: Albendazole 400mg plus Ivermectin 0.20 mg/kg as Single Dose to be repeated as per condition of patients.
Cutaneous larva migrans: Albendazole: 5 mg/kg/day plus Ivermectin 0.2 mg/kg/dose to be repeated as per conditionof patients.
HOW SUPPLIED:
BENDIGO PLUS SUSPENSION is available as oral suspension in10ml Pack.
References:
- Indian Pediatr. 2022 Dec 15;59(12):916-919. Epub 2022 Oct 29.
- Perth Children’s Hospital Children’s Antimicrobial Management Program (ChAMP)
- Am J Trop Med Hyg . 1999 Mar;60(3):479-86.
- Lancet Infect Dis 2022;22: 123–35
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