Therapy / Class: Antibacterial / Macrolide Class
Spectrum of Coverage:
Aerobic Gram-positive microorganisms | Atypical / Other microorganisms |
Streptococcus pyogenes | Chlamydophila pneumoniae |
Aerobic Gram-negative microorganisms | Legionella pneumophila |
Haemophilus influenzae | Mycobacterium avium |
Moraxella catarrhalis | Mycobacterium chelonae |
Helicobacter pylori | Mycobacterium intrazellulare |
Mycoplasma pneumoniae |
Mechanism of Action:
Works by stopping the growth of bacteria. It binds to the 50s ribosomal sub-unit of susceptible bacteria.
Indications:
- Infections of the upper respiratory tract such as tonsillitis/pharyngitis, as an alternative when betalactam antibiotics are not appropriate.
- Acute otitis media in children.
- Infections of the lower respiratory tract such as community acquired pneumonia.
- Sinusitis and acute exacerbation of chronic bronchitis in adolescents over 12 years of age
- Skin infections and soft tissue infections of mild to moderate severity.
Dosage & Administration:
| Children 6 months to 12 years of age | ||
|---|---|---|
| The recommended dose is 7.5 mg/kg twice a day. | ||
| Weight | Age | Dosage |
| 8 – 11 kg | 1 – 2 years | 2.5ml twice daily |
| 12 – 19 kg | 2 – 4 years | 5ml twice daily |
| 20 – 29 kg | 4 – 8 years | 7.5ml twice daily |
| 30 – 40 kg | 8 – 12 years | 10ml twice daily |
Children weighing less than 8 kg should be treated based on their bodyweight.
HOW SUPPLIED: CALOF-DS is Dry Syrup available as 30ml pack with sterile water
References:
- Gutiérrez-Castrellón P, et al. Meta-analysis of clarithromycin in children with respiratory infections. n ClRev Invest Clin 2012; 64 (2): 126-135
- Pediatr Infect Dis J. 1993 Dec;12(12 Suppl 3):S122-7
- Indian J Otolaryngol Head Neck Surg. 2018 Mar; 70(1): 87–91.
