Therapy/Class:
Therapy:
Cyproheptadine: Appetite Stimulant
Tricholine Citrate: Lipotropic Agent
Class:
Cyproheptadine: Piperidine Antihistamine
Tricholine citrate: Bile Acid Binding Agent
Mechanism of Action:
Cyproheptadine: It competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. It also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite centre of the hypothalamus may account for ability to stimulate appetite
Tricholine citrate: It contains three molecules of choline. Clinical interest in choline centres on its lipotropic action & its utility in the treatment of fatty infiltration and cirrhosis of liver. Choline converts fat into phospholipids like, lecithin, which is essential to bio membrane structure and its function. Lecithin is also a major component of high-density lipoprotein (HDL), and is used to mobilize cholesterol from cell membrane. In patients with fatty liver, increased rate of phospholipid turnover has been observed following administration of choline.
Indications:
In
- Loss of Appetite
- Weight Loss
- Anorexia Nervosa,
- As An Adjunct to Anti-Tubercular & Antiretroviral Regimens for Weight Gain
- In Underweight Children Who Have Inadequate Dietary Intake or Loss of Appetite & Children Suffering From Anaemia, Liver Or Digestive Disorder.
Dosage & Administration:
Cyproheptadine are 0.25 mg/kg/dose that have to be taken twice or thrice a day. It has been proved to be safe even for children less than 2 years of age.
The recommended dose of CYPOTALL Drops is as below
| Age | Concentration of drops (mg) | Volume of drops(ml) |
|---|---|---|
| Up to 6 months | 0.75 mg | 0.5 ml |
| 6 – 12 months | 1.5 mg | 1 ml |
| 1- 2 years | 1.5 – 3 mg | 1 -2 ml |
HOW SUPPLIED:
Cypotall Drops is available as drops in 15ml pack
Cypotall Syrup is available as Syrup in 110ml pack
References:
- Najib K, Moghtaderi M, Karamizadeh Z, Fallahzadeh E. Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial. Iran J Pediatr. 2014 Dec;24(6):753-8. Epub 2014 Dec 12. PMID: 26019782; PMCID: PMC4442838.
- Annals of International Medical and Dental Research, Vol (4), Issue (2), ISSN (O):2395-2822; ISSN (P):2395-2814
- Grunert J, van der Haak N, La Vanda C, Farrow N, Tai A. Cyproheptadine as an appetite stimulant in children with cystic fibrosis. Clin Nutr ESPEN. 2021 Apr;42:407-409. doi: 10.1016/j.clnesp.2021.01.015. Epub 2021 Feb 5. PMID: 33745614.
- Krasaelap A, Madani S. Cyproheptadine: A Potentially Effective Treatment for Functional Gastrointestinal Disorders in Children. Pediatr Ann. 2017 Mar 1;46(3):e120-e125. doi: 10.3928/19382359-20170213-01. PMID: 28287686.
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