Therapy/Class:
Therapy
Phenylephrine: Decongestant
Cetirizine: Antiallergic
Paracetamol: Analgesics with Antipyretic
Class
Phenylephrine: Selective Alpha-1 Adrenergic Agonist
Cetirizine: Second Generation Antihistamines
Paracetamol: Para Aminophenol Derivatives
Mechanism of Action:
Phenylephrine: It stimulates alpha-adrenergic receptors on the nasal mucosa (direct effect) causing vasoconstriction of local vessels. The vasoconstrictive action decreases mucosal edema, leading to a decongestant effect.
Cetirizine: It is a metabolite of hydroxyzine, is an antihistamine drug. Its main effects are achieved through selective inhibition of peripheral H1 receptors.
Paracetamol: Paracetamol primarily raises the pain threshold in the central nervous system (CNS) by inhibiting COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis. Its antipyretic properties result from direct effects on the hypothalamus, promoting peripheral vasodilation, sweating, and heat dissipation.
Indications:
- For relief of coughs and upper respiratory symptoms, including nasal congestion, associated with Fever, Allergy & Common Cold like sneezing, watery eyes or itchy/watery nose and throat.
Dosage & Administration:
In children 2 years to under 6 years of age
- 5ml once daily or 2.5ml every 12 Hrs
In children 6 years and over
- 10ml once daily or 5ml every 12 Hrs
HOW SUPPLIED:
KID-ZUKAM CTZ SUSPENSION is available as Suspension in 60ml Pack.
References:
- De Sutter AI, Eriksson L, van Driel ML. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst Rev. 2022 Jan 21;1(1):CD004976. 10.1002/14651858.CD004976.pub4. PMID: 35060618; PMCID: PMC8780136.
- Parisi GF, Leonardi S, Ciprandi G, Corsico A, Licari A, Miraglia Del Giudice M, Peroni D, Salpietro C, Marseglia GL. Cetirizine use in childhood: an update of a friendly 30-year drug. Clin Mol Allergy. 2020 Feb 26;18:2. doi: 10.1186/s12948-020-00118-5. PMID: 32127782; PMCID: PMC7043022.
- Stat Pearls, Show details Treasure Island (FL): Stat Pearls Publishing; 2023 Jan-.
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