Parajely Total Jelly

Composition: Each 5ml jelly contains Paracetamol 250mg + Phenylephrine 5mg + Chlorpheniramine 2mg in 60ml Pack. 

Formulation: JELLY

Flavour: Strawberry and Watermelon Flavour

Therapy / Class: Antipyretic, Decongestant & Anti-Allergic (Cough & Cold Combinations) / Paracetamol: Para Aminophenol Derivatives + Phenylephrine: alpha-1 adrenergic receptor agonist + Chlorpheniramine: Antihistamines

Mechanism of Action:

Paracetamol:

Analgesic Mechanism: It produces analgesic action by inhibiting the COX pathway in the central nervous system but not in peripheral tissues. It acts within the CNS to increase the pain threshold by inhibiting central cyclo-oxygenase (Both COX-1 & COX-2). 

Anti-Pyretic Mechanism: It also produces antipyretic effect by inhibiting PG synthesis in the central nervous system & blocking the actions of endogenous pyrogens at the hypothalamic thermo-regulatory centres.

Phenylephrine: It possesses both direct and indirect sympathomimetic effects, primarily as a post-synaptic alpha-adrenergic agonist, producing potent vasoconstriction. This constriction of blood vessels leads to reduced blood flow to the nose, decreased amount of blood in the sinusoid vessels, and decreased mucosal edema, which relieves nasal congestion.

Chlorpheniramine: It is a H1-antagonists which compete with free histamine for binding at H1-receptor sites. Blockade of H1-receptors suppresses the formation of edema, flare, and pruritus that result from histaminic activity.

Indications: For the Relief Symptoms of Common Cold or Flu
  • Cough
  • Fever
  • Headache
  • Mild Pain
  • Rhinorrhea
  • Sinus And Nasal Congestion
  • Sneezing
  • Sore Throat (Pharyngitis)

Dosage & Administration:

Children of age between 2 to 12 years (body weight – 6-40 kg): The usual recommended dose is
Age in years Weight in kg Dose
2–4 6–16.5 2.5ml TID
4–9 16.5–28.6 5ml BID
9–12 28.6–41.5 5ml TID
 
HOW SUPPLIED: PARAJELY TOTAL is available as jelly form in 60ml Pack.

References:

  1. BMC Infect Dis. 2013; 13: 556.
  2. International Journal of Basic & Clinical Pharmacology | January 2019 | Vol 8 | Issue 1    Page 34
  3. CMAJ. 2014 Feb 18; 186(3): 190–199.

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