Therapy/Class:
Therapy:
Dextromethorphan: Antitussive / Cough suppressant
Chlorpheniramine: Antiallergic
Class:
Dextromethorphan: NMDA receptors Antagonist
Chlorpheniramine: Antihistamine H1 Receptor Antagonist
Mechanism of Action:
Dextromethorphan:
It is an antitussive agent that works to suppress coughing. It acts on the cough centre in the brain to reduce the urge to cough, providing relief from dry and irritating coughs.
Chlorpheniramine:
It has H1-antagonist activity belonging to the alkylamine class of antihistamines and it appear to compete with histamine for receptor sites on effector cells. It antagonizes the allergic response vasodilatation, increased vascular permeability, increased mucus secretion of nasal tissue.
Indications:
- For relief of coughs and upper respiratory symptoms, associated with allergy or the common cold.
Dosage & Administration:
For Children Aged 6 to Under 12 years of age:
2.5ml to 5ml every 4 to 6 hours.
For Children Aged 2 to Under 6 years of age:
1.25ml to 2.5ml every 4 to 6 hours.
HOW SUPPLIED: TRUBERY JR SYRUP is available as Syrup in 60ml Pack.
References:
- Lam SHF, Homme J, Avarello J, Heins A, Pauze D, Mace S, Dietrich A, Stoner M, Chumpitazi CE, Saidinejad M. Use of antitussive medications in acute cough in young children. J Am Coll Emerg Physicians Open. 2021 Jun 18;2(3)
- Green JL, Wang GS, Reynolds KM, Banner W, Bond GR, Kauffman RE, Palmer RB, Paul IM, Dart RC. Safety Profile of Cough and Cold Medication Use in Pediatrics. Pediatrics. 2017 Jun;139(6)
