Therapy / Class: Nutritional: Nutritional Supplement / Trace Mineral Supplement (Zinc Salt of Gluconic Acid)
Mechanism of Action:
- It can treat acute and chronic diarrhoea by inhibiting three out of the four main intracellular pathways of intestinal ion secretion, including cyclic adenosine monophosphate (cAMP), calcium, and nitric oxide. It also decreases the concentration of copper by inducing the synthesis of a copper-binding ligand in mucosal cells; this sequesters copper, making it unavailable for serosal transfer in the GI tract.
- In common cold it is a competitive inhibitor of ICAM-1 in both rhinovirus particles and the nasal epithelium.
- It also aids in wound repair by acting as a cofactor in several transcription factors and enzyme systems (i.e., zinc-dependent matrix metalloproteinases) that augment auto-debridement and keratinocyte migration.
Indications:
- Enhances Immune system function.
- Growth & Development
- Diarrhoea Treatment (Co-Therapy in Oral Rehydration Therapy)
- Reduces Duration & Severity of Common Cold
- Fasten Wound Healing
Dosage & Administration:
Infants (Adequate Intake)
- 0 to 6 months: 2 mg per day (mg/day)
- 7 to 12 months: 3 mg/day
Children (Recommended Dietary Allowance)
- 7 to 12 months: 3 mg/day
- 1 to 3 years: 3 mg/day
- 4 to 8 years: 5 mg/day
- 9 to 13 years: 8 mg/day
- Supplementation Dose: 5 to 20 mg/day
HOW SUPPLIED: ZINGUT READYMIX is available as Syrup in 60ml pack.
References:
- Marshall, S. (1998). Zinc gluconate and the common cold. Review of randomized controlled trials. Canadian Family Physician, 44, 1037.
- Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016 Dec 20;12(12):CD005436.
- Kiran, D. M. D., Sheikh, S. N., & Pawaskar, L. J. (2018). Safety and Efficacy of a Zinc Gluconate Solution in Management of Paediatric Diarrhoea. International Journal of Medical Science and Clinical Invention, 5(8), 4020–4023.
- Ronald B. Turner, Wes E. Cetnarowski, Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds, Clinical Infectious Diseases, Volume 31, Issue 5, 15 November 2000, Pages 1202–1208.
- StatPearls, David Rabinovich; Yamen Smadi. Author Information and Affiliations Last Update: May 1, 2023.
