Ximclor Suspension

XIMCLOR SUSPENSION: Each 5ml suspension contains Chloramphenicol 125mg in 60ml Pack.

Formulation: Suspension

Flavour: Mix Fruit Flavour

Category:

Therapy / Class: Antibacterial / Amphenicol-class Antibacterial

Spectrum of Coverage:

  • Haemophilus Influenza
  • Neisseria meningitidis
  • Streptococcus pneumoniae
  • Salmonella enterica serotype Typhi
  • Rickettsia
  • Lymphogranuloma-psittacosis group
  • Escherichia coli
  • Staphylococcus aureus

Mechanism of Action:

Works by inhibiting protein synthesis by binding to the 50S ribosomal subunit & directly preventing the formation of bacterial protein. On a molecular level, chloramphenicol inhibits the attachment of transfer RNA to the A site on the 50S ribosome.

Indications:

  • Rickettsial Diseases
  • Meningitis
  • Typhoid Fever
  • Cholera

Dosage & Administration:

  • Moderate Infections: 50mg/kg/day, given in 4 divided doses at 6 hours interval.
  • Severe Infections (Meningitis & Bacteraemia): 100mg/kg/day, given in 4 divided doses at 6 hours interval with an attempt for dose reductions back to 50mg/kg/day made as soon as possible. Also, dose reductions to 25mg/kg/day may be necessary for neonates, and patients who have impaired liver or renal function.

HOW SUPPLIED:

XIMCLOR is available as oral suspension in 60ml Pack.

References:

  1. Cochrane Database Syst Rev. 2017 Jun 14;6(6)
  2. Infect Drug Resist. 2019; 12:3217-3225
  3. J Chemother. 2016 Jun;28(3):143-50

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