Therapy / Class: Antibacterial / Polymyxin Antibiotics
Spectrum of Coverage:
Aerobic gram-negative microorganisms
- Enterobacter aerogenes
- Escherichia coli
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
Mechanism of Action:
Colistin exhibits bactericidal activity & it is a surface-active agent which penetrates into and disrupts the bacterial cell membrane. This causes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing.
Indications:
- Bacterial Infections of The Gut (Stomach & Intestines)
Selective - Decontamination of The Digestive Tract in ICU
Dosage & Administration:
2.5 to 5mg/kg/day in 2-4 divided doses
HOW SUPPLIED:
COLIZING is available as Dry Syrup in 30ml Pack.
COLIZING DS is available as Dry Syrup in 30ml Pack.
References:
- Southeast Asian J Trop Med Public Health. 2004 Mar;35(1):181-7
- JAC-Antimicrobial Resistance, Volume 3, Issue 2, June 2021
- Clinical Infectious Diseases, Volume 40, Issue 9, 1 May 2005, Pages 1333–1341
- July 2012, Pediatric Critical Care Medicine 14(1)
