Matafix CV Dry Syrup


METAFIX CV50 Dry Syrup: Each 5ml contains Cefixime 50mg & Clavulanic Acid 31.25mg in 30ml pack. 

METAFIX CV100 DRY SYRUP : EACH 5ML CONTAINS Cefixime 100mg & Clavulanic Acid 62.5mg in Dispersible Tablet

Formulation: Dry Syrup


METAFIX CV 50- Mango Flavour

METAFIX CV100- Orange and Vanilla Flavour


Therapy / Class: Antibacterial / Third-Generation Cephalosporin Antibiotic plus β-lactamase inhibitor

Spectrum of Coverage: 

Gram-positive bacteria (β-lactamase Producing Strains) 

  • Streptococcus pneumoniae
  • Streptococcus pyogenes

Gram-negative bacteria (β-lactamase Producing Strains) 

  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Escherichia coli
  • Proteus mirabilis
  • Neisseria gonorrhoeae

Mechanism of Action:

Cefixime shows bactericidal action by inhibition of bacterial cell wall synthesis. It is found to be ineffective against bacteria that produce ESBL enzymes and resistance is seen in such types of bacteria. Clavulanic acid contains a beta-lactam ring in its structure that binds in an irreversible fashion to beta-lactamases, preventing them from inactivating Cefixime. The combination of cefixime and clavulanic acid (β-lactamase inhibitor) provides a solution for treatment of bacterial infections caused by β-lactam resistant Bacteria.

Indications: (In β lactamase Resistant Infections)

  • Typhoid Fever / Quinolone-Resistant Uncomplicated Typhoid Fever
  • Otitis Media
  • Pharyngitis & Tonsillitis
  • Acute Bacterial Sinusitis
  • Acute Exacerbations of Chronic Bronchitis
  • Uncomplicated Urinary Tract Infection (UTI)
  • Community-Acquired Pneumonia due to Haemophilus influenzae

Dosage & Administration:

Paediatric Patients (6 months or older): Dose of Cefixime is considered for treatment of all Infections 8mg/kg/day of the suspension & may be administered as a single daily dose or may be given in two divided doses, as 4mg/kg every 12 hours.

Duration of therapy: Ranges from 3 to 14 Days depending on type & severity of Infection


Patient Weight (kg)

Dose/Day (mg)

5 to 6.2


6.3 to 12.5


12.6 to 18.8 


18.9 to 25


25.1 to 31.3


31.4 to 37.5


37.6 to 43.8


43.9 to 50 



METAFIX CV 50 Dry Syrup is a Dry Syrup available as 30ml pack with sterile water


  1. Southeast Asian J Trop Med Public Health. 2009 Jan;40(1):131-9.
  2. Ann Clin MicrobiolAntimicrob. 2022 May 22;21(1):20. 
  3. J AntimicrobChemother. 2021 Oct 11;76(11):2839-2846. 


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