Therapy / Class: Antiallergic, Antiemetics & Antinauseants / First Generation Antihistamine
Mechanism of Action:
It competes with histamine for H1-receptor sites on the effector cell surface. Blockade of H1-receptors also suppresses the formation of edema, flare, and pruritus that result from histaminic activity. The sedative properties of hydroxyzine occur at the subcortical level of the CNS & this effect may be dose related. It also has some antiemetic actions secondary to its central anticholinergic actions.
Indications:
- Treatment of pruritus due allergic conditions, such as chronic urticaria, atopic dermatitis, or contact dermatitis, and histamine-mediated pruritus.
- Treatment of Nausea/Vomiting
- Treatment of Post-operative Nausea/Vomiting (PONV)
- Prophylaxis of Post-operative Nausea/Vomiting (PONV)
- For the short-term treatment of anxiety, tension, and psychomotor agitation in conditions of emotional stress
Dosage & Administration:
- Children 1 to 5 years weighing 40 kg or less: 50 mg/day PO in 3 to 4 divided doses as needed.
- Children 1 to 5 years weighing more than 40 kg: 50 mg/day PO in 3 to 4 divided doses as needed.
- Children and Adolescents 6 to 17 years: 50 to 100 mg/day PO in 3 to 4 divided doses as needed.
A maximum of 2 mg/kg/day is recommended.
HOW SUPPLIED: HYTWIST SYRUP is available as Syrup in 100ml Pack.
References:
- Burgazli CR, Rana KB, Brown JN, Tillman F 3rd. Efficacy and safety of hydroxyzine for sleep in adults: Systematic review. Hum Psychopharmacol. 2023 Mar;38(2):e2864.
- Llorca PM, Spadone C, Sol O, Danniau A, Bougerol T, Corruble E, Faruch M, Macher JP, Sermet E, Servant D. Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study. J Clin Psychiatry. 2002 Nov;63(11):1020-7.
- Guaiana G, Barbui C, Cipriani A. Hydroxyzine for generalised anxiety disorder. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD006815.
