Therapy/Class:
Therapy
Mefenamic Acid: Analgesic, Anti-Inflammatory & Antipyretic
Paracetamol: Analgesics & Antipyretic
Class
Mefenamic Acid: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Paracetamol: Para Aminophenol Derivatives
Mechanism of Action:
Mefenamic Acid: Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signalling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Paracetamol: Paracetamol primarily raises the pain threshold in the central nervous system (CNS) by inhibiting COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis. Its antipyretic properties result from direct effects on the hypothalamus, promoting peripheral vasodilation, sweating, and heat dissipation.
Indications:
In Mild to Moderate Pain associated with….
- Flu, Cold or Fever
- Teething / Immunization
- Tonsillitis / Pharyngitis
- Otitis Media
- Onset of Menses
- Muscular/Sport Injury
- Migraine
Dosage & Administration:
6 months-2 years age:
Mefta-Sip Suspension & Mefta-Sip Jelly: 1 table spoonful BID or TID
2-5 years age:
Mefta-Sip Forte Suspension & Mefta-Sip Forte Jelly: 1- 2 table spoonful BID or TID
HOW SUPPLIED:
Mefta-Sip Suspension is available as Suspension in 60ml Pack.
Mefta-Sip Forte Suspension is available as Suspension in 60ml Pack.
Mefta-Sip Jelly is available as Jelly in 60ml Pack.
Mefta-Sip Forte Jelly is available as Jelly in 60ml Pack.
References:
- Loya A, Siddiqui MS, Sangle A, Ingale V, Saha S, Nelanuthala M. The Antipyretic Effect of High-Dose Paracetamol Versus Mefenamic Acid in the Treatment of Febrile Children: A Randomized Control Trial. Cureus. 2022 Jul 11;14(7):e26733. doi: 10.7759/cureus.26733. PMID: 35967183; PMCID: PMC9363685.
- South African Family Practice is co-published by Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor & Francis Group South African Family Practice 2014; 56(4):212 215http://dx.doi.org/10.1080/20786190.2014.953860
- Khubchandani RP, Ghatikar KN, Keny S, Usgaonkar NG. Choice of antipyretic in children. J Assoc Physicians India. 1995 Sep;43(9):614-6. PMID: 8773063.
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