Therapy:
Amoxycillin: Antibacterial
Clavulanic Acid: Beta Lactamase Inhibitor /
Class:
Amoxycillin: Semi-synthetic Aminopenicillin
Clavulanic Acid: β-lactam related to penicillins.
Spectrum of Coverage:
Gram-positive bacteria
- Staphylococcus aureus
- Enterococcus faecalis
- Staphylococcus epidermidis
- Staphylococcus saprophyticus
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Viridans group Streptococcus
Gram-negative bacteria
- Enterobacter species
- Escherichia coli
- Haemophilusinfluenzae
- Klebsiella species
- Moraxella catarrhalis
- Eikenellacorrodens
- Proteus mirabilis
Anaerobic Bacteria
- Bacteroides species includingBacteroidesfragilis
- Fusobacterium species
- Peptostreptococcus species
Mechanism of Action:
Amoxycillin: It exhibits bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide by acting on Penicillin Binding Proteins on Bacterial Cell Wall.
Clavulanic Acid: Itis a beta-lactamstructurally related to the penicillins,possesses the ability to inactivate some beta-lactamase enzymes commonly found inmicro-organisms resistant to penicillins and cephalosporins. It has good activityagainst the clinically important plasmid-mediated beta-lactamases frequently responsible fortransferred drug resistance.
The formulation of amoxicillin and clavulanic acid protects amoxicillin from degradation by some beta lactamase enzymes and extends the antibiotic spectrum of amoxicillinto include many bacteria normally resistant to amoxicillin.
Indications:
- Lower Respiratory Tract Infections
- Acute Bacterial Otitis Media
- Sinusitis
- Skin and Skin Structure Infections
- Urinary Tract Infections
Dosage & Administration:
Dosing in Patients Aged 12 weeks (3 months) and Older | ||
INFECTION | DOSING REGIMEN | |
Every 12 hours | Every 8 hours | |
200mg/5mL OR 400mg/5mL oral suspension | 125mg/5mL OR 250mg/5mL oral suspension | |
Otitis media, Sinusitis, Lower Respiratory Tract Infections, & more severe infections | 45mg/kg/day every 12 hours | 40mg/kg/day every 8 hours |
Less severe infections | 25mg/kg/day every 12 hours | 20mg/kg/day every 8 hours |
Neonates and Infants Aged <12 weeks (<3 months): 30mg/kg/day divided every 12hours, based on the amoxicillin part.
HOW SUPPLIED:
MOXPEDIA-CV DT is available asDispersible Tablet in 1×10 Strip.
MOXPEDIA-CV 375 TABLET is available asTablet in 1×10 Strip.
References:
- Journal of International Medical Research,Research article First published July-August 1990
- Can Fam Physician. 2017 Sep; 63(9): 685–687.
- PediatrClin North Am. 2003 Apr; 50(2): 413–426
- Pediatrics (2009) 124 (1): 9–15.
- J Clin Med. 2019 Aug; 8(8): 1162.
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