Parajely-125 DT

Composition: Each Tablet contains Paracetamol 125mg in Dispersible Tablet in 1 x 10 Tablets.

Formulation: Dispersible Tablets

Flavour: Strawberry Flavour

Category:

Therapy / Class: Analgesics & Antipyretic / Para Aminophenol Derivatives

Mechanism of Action:

Analgesic Mechanism: It produces analgesic action by inhibiting the COX pathway in the central nervous system but not in peripheral tissues. It acts within the CNS to increase the pain threshold by inhibiting central cyclo-oxygenase (Both COX-1 & COX-2). 

Anti-Pyretic Mechanism: It also produces antipyretic effect by inhibiting PG synthesis in the central nervous system & blocking the actions of endogenous pyrogens at the hypothalamic thermo-regulatory centres.

Indications:

  1. Treatment Of Fever
  2. Treatment of Mild Pain or for the temporary relief of
    • Headache
    • Myalgia
    • Back Pain
    • Musculoskeletal Pain
    • Dental Pain (E.G., Toothache)
    • Dysmenorrhea, Arthralgia
    • Minor Aches & Pains Associated with Common Cold or Flu
  3. Moderate Pain to Severe Pain with Adjunctive Opioid Analgesics
  4. Acute Treatment of Migraine

Dosage & Administration:

For Suspension/Dispersible Tablets

Age Group

Dose given every 4 hours

Dose given every 6 hours

Maximum single dose

Maximum total daily dose of Paracetamol 

Children 2 to 12 years of age 

12.5mg/kg

15mg/kg 

15mg/kg (up to 750mg)

75mg/kg in 24 hours (up to 3,750mg)

For Drops

Average Weight (Kg)

Dose* (ml)

3.8-5.5

0.5-0.8

5.5-8.3

0.8-1.2

8.3-10

1.2-1.5

*Calculated based on 15mg/kg body weight

HOW SUPPLIED: PARAJELY-125 DT is available as Dispersible Tablet in 1×10 Strip.

References:

  1. Cochrane Database Syst Rev. 2002;2002(2)
  2. Scand J Prim Health Care. 2010; 28(2): 115–120.
  3. Eur J Pediatr. 2022 May;181(5):1835-1857. 
  4. Inflammopharmacology. 2017; 25(1): 1–9.
  5. Pain Ther. 2015 Dec;4(2):149-68.

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