Oflopedia OR Suspension

Ofloxacin: Bactericidal at concentrations equal to or slightly greater than inhibitory concentrations. It inhibits bacterial topoisomerase IV & DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair, and recombination.

Ornidazole: It is a newer 5-nitroimidazole class of antibiotic with superior efficacy and longer duration of action. It has an antibacterial effect like that of metronidazole and other 5-nitroimidazoles. It kills susceptible microorganisms by interfering with DNA functioning. It acts selectively against microorganisms with enzyme systems capable of reducing the nitro group and catalyzing the interaction between ferredoxin proteins and nitro compounds. After the drug penetrates the microbial cell, the mechanism of its action is based on reducing the nitro group under the influence of the microorganism’s nitroreductases and the activity of the reduced nitroimidazole. The reduction products create compounds with DNA causing it to degrade and disrupt the DNA replication and transcription processes. Furthermore, the drug’s metabolism products have cytotoxic properties and disrupt cellular respiration processes.

Racecadotril: It rapidly converted in the body to thiorphan, a potent enkephalinase inhibitor. Enkephalins are endogenous opioid peptides secreted by myenteric and sub mucosal neurons in the digestive tract. The enkephalins by activating the δ opioid receptor, inhibit the secretion of Cl– and fluids thus reducing the loss of fluids and electrolytes during diarrhea. The antisecretory mechanisms are independent of effects on intestinal motility, differentiating this compound from μ-opiate receptor agonists like loperamide and diphenoxylate.