Therapy / Class: Antibacterial / Fluoro-quinolone Antibiotics
Spectrum of Coverage:
Aerobic Gram-positive microorganisms
- Staphylococcus aureus (methicillin-susceptible strains)
- Streptococcus pneumoniae (penicillin-susceptible strains)
- Streptococcus pyogene
Aerobic Gram-negative microorganisms
- Citrobacter (diversus) koseri
- Enterobacter aerogenes
- Escherichia coli
- Haemophilus influenzae
- Klebsiella pneumoniae
- Neisseria gonorrhoeae
- Proteus mirabilis
- Pseudomonas aeruginosa
Mechanism of Action:
Indications:
- Typhoid Fever
- Multidrug-Resistant Uncomplicated Typhoid Fever
- Gastro Intestinal Infections
- Acute Otitis Media
- Urinary Tract Infection
- Bubonic or Pharyngeal Plague
- Pneumonic or Septicemic Plague
- Plague Prophylaxis (Pre & Post Exposure)
Dosage & Administration:
Typhoid Infections & Multidrug-Resistant Uncomplicated Typhoid Fever: 15 to 30mg/kg/day orally divided twice daily (Max: 400mg/dose) for 5 to 10 days.
Plague Infections:
Pre-Plague -Exposure Prophylaxis: 7.5mg/kg/dose (Max: 400mg/dose) orally every 12 hours until 48 hours after the last perceived exposure as an alternative therapy.
Post Plague -Exposure Prophylaxis: 7.5mg/kg/dose (Max: 400mg/dose) orally every 12 hours for 7 days as an alternative therapy.
Pneumonic or Septicemic Plague: 7.5mg/kg/dose (Max: 400mg/dose) orally every 12 hours for 10 to 14 days as an alternative therapy.
HOW SUPPLIED:
OFLOPEDIA is available as oral suspension in 60ml Pack.
OFLOPEDIA DS is available as oral suspension in 60ml Pack.
References:
- Pediatr Infect Dis J. 1999 Mar;18(3):245-8
- Journal of Clinical and Diagnostic Research. 2012 December, Vol-6(10): 1736-1739
- World Health Organization; 2021.
