Therapy / Class: Antibacterial / 3rd Generation Cephalosporin Antibiotics

Spectrum of Coverage:

Aerobic Gram-Positive Microorganisms:

Staphylococcus aureus (including β-lactamase producing strains)
Streptococcus pneumoniae
Streptococcus pyogenes

Aerobic Gram-Negative Microorganisms:

Haemophilus influenzae (including β-lactamase producing strains)
Haemophilus parainfluenzae (including β-lactamase producing strains)
Moraxella catarrhalis (including β-lactamase producing strains)

Mechanism of Action:

Bactericidal activity of cefdinir results from inhibition ofcell wall synthesis & it is stable in the presence of some, but not all, β-lactamase enzymes.

Indications:

Acute Bacterial Otitis Media
Pharyngitis/Tonsillitis
Uncomplicated Skin and Skin Structure Infections
Acute Maxillary Sinusitis
Community-Acquired Pneumonia (CAP)

Dosage & Administration:

Paediatric Patients (Age 6 Months Through 12 Years)
Type of Infection	Dosage	Duration
Acute Bacterial Otitis Media	7 mg/kg q12h or 14 mg/kg q24h	5 to 10 days 10 days
Acute Maxillary Sinusitis	7 mg/kg q12h or 14 mg/kg q24h	10 days 10 days
Pharyngitis/Tonsillitis	7 mg/kg q12h or 14 mg/kg q24h	5 to 10 days 10 days
Uncomplicated Skin & Skin Structure Infections	7 mg/kg q12h	10 days