Therapy / Class: Antibacterial / 2nd Generation Cephalosporin Antibiotics
Spectrum of Coverage:
Gram-positive bacteria
- Staphylococcus aureus (methicillin-susceptible isolates only)
- Streptococcus pneumoniae
- Streptococcus pyogenes
Gram-negative bacteria
- Escherichia coli
- Klebsiella pneumoniae
- Haemophilus influenzae
- Haemophilus parainfluenzae
- Moraxella catarrhalis
- Neisseria gonorrhoeae
Spirochetes
- Borrelia burgdorferi
Mechanism of Action:
Bactericidal action by inhibition of bacterial cell wall synthesis. It has activity in the presence of some β-lactamase both penicillinases & cephalosporinases, of gram-negative and gram-positive bacteria.
Indications:
- Pharyngitis/Tonsillits
- Acute Bacterial Otitis Media
- Acute Bacterial Maxillary Sinusitis
- Acute Bacterial Exacerbations of Chronic Bronchitis
- Secondary Bacterial Infections of Acute Bronchitis
- Uncomplicated Skin & Skin-Structure Infections
- Impetigo
- Uncomplicated Urinary Tract Infections
- Early Lyme disease
Dosage & Administration:
| Dosage Guidelines Paediatric Patients (3 months to 12 years) | ||||||
| Infection | Recommended Daily Dose | Maximum Daily Dose | Duration (Days) | |||
| Pharyngitis/Tonsillitis | 20mg/kg | 500mg | 10 | |||
| Acute Bacterial Otitis Media | 30mg/kg | 1,000mg | 10 | |||
| Acute Bacterial Maxillary Sinusitis | 30mg/kg | 1,000mg | 10 | |||
| Impetigo | 30mg/kg | 1,000mg | 10 | |||
| Paediatric Patients younger than 13 years (who can swallow tablets whole) | ||||||
| Infection | Dosage | Duration (Days) | ||||
| Acute Bacterial Otitis Media | 250mg every 12hours | 10 | ||||
| Acute Bacterial Maxillary Sinusitis | 250mg every 12hours | 10 | ||||
HOW SUPPLIED:
PULMOPEDIA TABLET is available as Tablet in 10 x 10 Aluminum Strip
References:
- Chemotherapy. 2004 Apr;50(1):51-4.
- J Chemother. 1992 Aug;4(4):221-4.
- Pediatric Infectious Disease, Volume 3 Issue 4 (October–December 2021)
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