Xifatic M Suspension

Composition:

XIFATIC M SUSPENSION: Each 5ml suspension contains Rifaximin 100mg & Metronidazole 200mg in 60ml Pack.

Formulation: Suspension

Flavour: Mango Flavour ;

Category:

Therapy / Class: Antibacterial / Rifamycin Class / Non-Systemically Absorbed Antibiotic

Spectrum of Coverage: Active against following pathogens (Including ammonia producing bacteria)

  • Non-invasive strains of Escherichia coli spp (entero toxigenic and entero aggregative strains)
  • Clostridium spp
  • Entero bacteriaceae
  • Bacteroides fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus)
  • Fusobacterium species
  • Eubacterium species 
  • Peptococcus species
  • Pepto streptococcus species
  • Gram-negative anaerobes 

Mechanism of Action:

Semi-synthetic derivative of rifampin & acts by binding to the beta-sub unit of bacterial DNA-dependent RNA polymerase blocking one of the steps in transcription. This results in inhibition of bacterial protein synthesis & consequently inhibits the growth of bacteria.

Indications:

  • Traveller’s Diarrhoea (TD)
  • Treatment of Small Intestinal Bacterial Over Growth
  • Irritable Bowel Syndrome

Dosage & Administration: 

  • Travelers’ Diarrhoea (TD): >= 12 years: 600mg/day orally for Traveler’s Diarrhoea.
  • Treatment of Small Intestinal Bacterial Over Growth:
    • Children 3 to 7 years: 200mg orally 3 times daily for 7 to 10 days
    • Children & Adolescents 8 to 17 years: 200 to 550mg orally 3 times daily for 7 to 10 days.
  • Irritable Bowel Syndrome: 600mg/day for 7 days

HOW SUPPLIED:

XIFATIC M is available as oral suspension in 60ml Pack.

References:

  1. J AntimicrobChemother. 2001 Jun;47(6):904-5.
  2. Therap Adv Gastroenterol. 2011 Jul; 4(4): 227–235.
  3. European Review for Medical and Pharmacological Sciences, 2013; 17: 1314-1320

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