Therapy/Class:
Therapy
Ibuprofen: Non-Steroidal Anti-Inflammatory Drug (NSAID)
Paracetamol: Analgesics with Antipyretic
Class
Ibuprofen: Propionic Acid Derivative
Paracetamol: Para Aminophenol Derivatives
Mechanism of Action:
Ibuprofen: it is a non-selective inhibitor of cyclooxygenase, which is an enzyme involved in prostaglandin (mediators of pain and fever) and thromboxane (stimulators of blood clotting) synthesis via the arachidonic acid pathways. It is a non-selective COX inhibitor and hence, it inhibits the activity of both COX-1 and COX-2. The inhibition of COX-2 activity decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever, and swelling.
Paracetamol: Paracetamol primarily raises the pain threshold in the central nervous system (CNS) by inhibiting COX-1, COX-2, and COX-3 enzymes involved in prostaglandin synthesis. Its antipyretic properties result from direct effects on the hypothalamus, promoting peripheral vasodilation, sweating, and heat dissipation.
Indications:
Short-Term Management of Mild to Moderate Acute Pain like…
- Muscle & Joint Pain
- Dysmenorrhea (Painful Periods or Menstrual Cramps)
- Dental Pain
- Reduces Fever
- Ear Pain
Dosage & Administration:
HOW SUPPLIED:
References:
- Vyas FI, Rana DA, Patel PM, Patel VJ, Bhavsar RH. Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children. Perspect Clin Res. 2014 Jan;5(1):25-31
- Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Database Syst Rev. 2013 Oct 30;2013(10):CD009572
- Parri, N., Silvagni, D., Chiarugi, A. et al. Paracetamol and ibuprofen combination for the management of acute mild-to-moderate pain in children: expert consensus using the Nominal Group Technique (NGT). Ital J Pediatr 49, 36 (2023).
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